Oflotas OZ Syrup 30ml
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Introduction About OFLOTAS OZ SYRUP
OFLOTAS OZ SYRUP is a combination of Ornidazole and Ofloxacin which belongs to the group of medicines called Antibiotics. OFLOTAS OZ SYRUP is used in children to manage various bacterial infections involving the blood (such as septicemia), brain (such as meningitis), lungs (such as pneumonia, bronchitis), ear and nose (such as sinusitis), urinary tract (such as cystitis), genital infections (including both the male and female genital organs), wound (post-operative infections) and stomach (such as peritonitis). OFLOTAS OZ SYRUP is also used as prophylaxis to manage bacterial infections during surgical interventions (particularly involving the colon and in gynaecological operations).
Before initiating the management with OFLOTAS OZ SYRUP to your child, your child’s doctor may recommend your child to take relevant medical tests to understand the existing condition and to properly use this medicine. Before giving OFLOTAS OZ SYRUP to your child, inform your child’s doctor if your child have heart disease (such as irregular heartbeat, valve disorder, poor heart function), kidney diseases (such as kidney failure or kidney injury), inflammation of the intestine, fits/seizure, autoimmune disease (such as multiple sclerosis), weak tendons (tendonitis, tendon rupture, rotator cuff), liver disease, psychiatric illness or emotional imbalances.
OFLOTAS OZ SYRUP is not recommended for use in pregnant or breastfeeding women and elderly individuals as it is used only in children. It is for pediatric use only. The common side effects of taking OFLOTAS OZ SYRUP are nausea, vomiting, diarrhea, headache, itching and changes in taste sensation. Consult your child’s doctor immediately if any of the side effects worsen during or after management with OFLOTAS OZ SYRUP.
Uses Of OFLOTAS OZ SYRUP
It is used to manage bacterial infections in children such as:
- Lungs infections (Ex. pneumonia, bronchitis)
- Sinus infections
- Urinary tract infections
- Meningitis
- Septicemia
- Peritonitis
- Post-operative wound infections
- Genital infections (both the male and female genital organs)
- Prophylaxis during surgical interventions (particularly involving the colon and in gynaecological operations)
How OFLOTAS OZ SYRUP Works
OFLOTAS OZ SYRUP is a combination of Ornidazole and Ofloxacin where Ornidazole works against the parasites and bacteria that live in the absence of oxygen by generating harmful molecule which damages the DNA of the parasites and bacteria and ofloxacin is a quinolone antibiotic that works against the bacteria by inhibiting the synthesis of bacterial DNA, hence OFLOTAS OZ SYRUP helps to manage various infections.
How to use OFLOTAS OZ SYRUP
Give OFLOTAS OZ SYRUP to your child as advised by the physician. Use a measuring cup to properly measure the dose. Your child’s doctor will decide the correct dose, duration and frequency of OFLOTAS OZ SYRUP for your child depending on child’s age, body weight and disease condition.
Side Effects Of OFLOTAS OZ SYRUP
Common
- Headache, dizziness
- Nausea, vomiting
- Diarrhea
- Itching
- Sleep problems
- External genital itching
- Vaginal inflammation
- Changes in taste sensation
Uncommon
- Stomach pain or discomfort
- Dry mouth
- Loss of appetite
- Fungal infection
- Agitation, restlessness
- Burning or irritation of the eye
- Cough and inflamed sore nose or throat
- Spinning sensation of the head (vertigo)
Rare
- Fast heartbeat
- Drowsiness
- Confusion, nightmare
- Decrease in blood sugar levels
- Depression or hallucination (feeling or hearing things not there)
- Changes in sensation of smell
- Shortness of breath or wheezing
- Excessive sweating
- Feeling faint, lightheadedness due to low blood pressure
- Hives
- Rash with pimples
- Pain or swelling around joints (tendonitis)
- Excessive sweating, hot flushes
Stop giving OFLOTAS OZ SYRUP to your child and contact doctor immediately if your child experiences any of the following side effects:
- Severe allergic reactions (such as skin rash, itching, swelling of the face, lips, tongue and other parts of the body, difficulty in breathing or wheezing, blisters on the skin, sore throat, fever, headache)
- Painful skin rashes with blisters and peeling or scaling of the skin in conditions such as steven-johnson syndrome and toxic epidural necrolysis
- Abnormal heartbeat
- Changes in behavior, psychosis, depression, hallucination, disorientation or fainting
- Impaired vision or hearing
- Severe fever, body chills or muscle pain
- Swelling or rupture of tendons
- Numbness or tingling sensation of the skin
- Abnormal bleeding
- Abnormal body movements like fits or seizure
- Severe loose stools or diarrhea
- Difficulty in passing urine or urine discoloration
- Loss of consciousness
- Abnormal body sugar level
- Pain, burning, numbness and/or weakness especially in the feet and legs or hands and arms (which indicates nerve damage)
- Stomach pain, itching, dark urine or yellowish discoloration of the skin and in the white part of the eye (jaundice)
How To Manage Side Effects
Diarrhea
Advise your child to drink plenty of water and stay hydrated. Avoid giving your child a high-fat diet or spicy foods. Try to avoid giving any medicine on your own to your child to manage diarrhea. Consult child’s doctor if the symptom gets worse.
Dry Mouth
Tell your child to sip water regularly and other sugar free liquids. Advise them not to use mouthwashes that contain alcohol because they can make your mouth dry, use mouthwash that is used only for dry mouth. Consult child’s doctor if the symptom gets worse.
Headache
Apply hot or cold-water bag on your child’s head. Advise your child to take rest in a quiet room. Massage child’s scalp or head with mild pressure for relieving effect. Consult child’s doctor if the symptom does not improve.
Nausea And Vomiting
Follow simple meal plan for your child while administering OFLOTAS OZ SYRUP. Avoid giving foods that are oily, fried or spicy foods. Do not let your child to lie down or sleep immediately after eating. Consult child’s doctor if the symptom does not improve.
Warning & Precautions
Driving and Using Machines
Use with CautionDo not let your child ride bicycles or drive other vehicles or operate any tools after taking OFLOTAS OZ SYRUP if your child feel dizzy, tired, sleepy, temporary loss of consciousness, less alert, spinning sensation of the head (vertigo), impaired vision, shivering, abnormal body movements and seizure/fits. Consult your child’s doctor for advice before administration of OFLOTAS OZ SYRUP.
Kidney
Use with CautionOFLOTAS OZ SYRUP should be administered with caution in children with kidney disease or problems. Consult your child’s doctor for advice before administration of OFLOTAS OZ SYRUP.
Liver
Use with CautionOFLOTAS OZ SYRUP should be administered with caution in children with liver disease. Consult your child’s doctor for advice before administration of OFLOTAS OZ SYRUP.
Allergy
ContraindicatedDo not give OFLOTAS OZ SYRUP to your child if they are allergic to Ofloxacin or Ornidazole. Also, inform child’s doctor if your child is allergic to other quinolone antibiotics such as ciprofloxacin, norfloxacin.
Heart Disease
Use with CautionOFLOTAS OZ SYRUP should be administered with caution in children with leaking heart valves (heart valve regurgitation), endocarditis (infection of the heart), irregular or slow heartbeat, family history of prolonged QT interval, weak heart (heart failure), family history of heart attack (myocardial infarction). Consult your child’s doctor for advice before administration of OFLOTAS OZ SYRUP.
Use In Pediatrics
Consult your doctorOFLOTAS OZ SYRUP can be used in children. Consult your child’s doctor for advice before administration of OFLOTAS OZ SYRUP to your child.
Others
OFLOTAS OZ SYRUP is not recommended for use, if your child:
- Has epilepsy or at risk of fits
- Has any pre-exisiting central nervous system (CNS) disorders
- Has history of inflammation and swelling of the tendons (tendonitis) especially after the management with quinolone antibiotics such as ciprofloxacin, norfloxacin or nadifloxacin
- Is suffering from or have a family history of glucose-6-phosphate dehydrogenase deficiency (an inherited disorder that affects the red blood cells)
Before giving OFLOTAS OZ SYRUP to your child, inform child’s doctor if your child:
- Has enlargement or bulge of a large blood vessel (aortic aneurysm or large vessel peripheral aneurysm)
- Has experienced a previous episode of aortic dissection (a tear in the aorta wall)
- Has a family history of aortic aneurysm or aortic dissection
- Has other risk factors or predisposing conditions (Ex. connective tissue disorders such as marfan syndrome or ehlers- danlos syndrome, turner syndrome, sjogren’s syndrome (an inflammatory autoimmune disease)
- Has vascular disorders such as takayasu arteritis, giant cell arteritis, behcet’s disease and high blood pressure or atherosclerosis, arthritis
- Has or ever had a history of mental illness
- Has salt imbalance in the blood (especially low level of potassium or magnesium in the blood)
- Has illness of the nervous system called myasthenia gravis (muscle weakness)
- Has diabetic or suffer from low blood sugar
- Has due to urine tests for porphyrin (a pigment in the blood) or for opiates (strong painkillers)
Interactions
A. Drug-Drug interactions:
Before giving OFLOTAS OZ SYRUP to your child, inform to child’s doctor if your child is taking or receiving any of the following medicines:
- Antipsychotics such as olanzapine, clozapine (used to manage psychosis)
- Cyclosporin (used to manage organ rejection after transplant)
- Quinidine, hydroquinidine, disopyramide, amiodarone, sotalol, dofetilide, ibutilide, pentoxifylline (used to manage irregular heart rhythm)
- Lithium or tricyclic antidepressants such as clomipramine, amitriptyline (used to manage depression)
- Macrolides such as erythromycin, clarithromycin, azithromycin (used to manage bacterial infection)
- Vecuronium bromide (used to relax muscles)
- Phenytoin, phenobarbital (used to manage epilepsy)
- Didanosine (used in the management of HIV infection)
- Furosemide (used to manage body fluid retention)
- Sucralfate, cimetidine (used to manage stomach ulcer)
- Antacids containing magnesium or aluminium (used for indigestion)
- Corticosteroids such as prednisolone, dexamethasone (used to manage inflammation)
- Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or diclofenac (used to pain and inflammation)
- Theophylline (used to manage asthma)
- Insulin, glibenclamide (used to manage diabetes)
- Probenecid (used to manage gout)
- Methotrexate (used for rheumatism)
- Warfarin, acenocoumarin, phenprocoumon (used to manage or manage blood clot)
- Medicines or dietary supplements that contain iron (for anemia) or zinc
- Herbal medicines
Overdosage:
If your child or anyone else accidentally takes too much of OFLOTAS OZ SYRUP, consult your child’s doctor immediately or visit the nearby hospital. Overdosage symptoms of OFLOTAS OZ SYRUP include confusion, dizziness, loss of consciousness, seizure or fit and nausea.
Synopsis
| Drug | : | Ornidazole, Ofloxacin |
| Pharmacological Category | : | Nitroimidazole, Fluoroquinolones |
| Therapeutic Indication | : | Various bacterial infections in children |
| Dosage Forms | : | Tablet, Capsule, Infusion, Injection, Syrup, Oral Suspension |
More Information
Storage
- Keep OFLOTAS OZ SYRUP out of reach from children
- Store OFLOTAS OZ SYRUP at room temperature
FAQs About OFLOTAS OZ SYRUP
Q: Does OFLOTAS OZ SYRUP cause diarrhea?
A: Yes, OFLOTAS OZ SYRUP may cause side effects like diarrhea in children. Advise your child to drink plenty of water and stay hydrated. Avoid giving your child a high-fat diet or spicy foods. Try to avoid giving any medicine on your own to your child to manage diarrhea. Consult child’s doctor if the symptom gets worse during or after management with OFLOTAS OZ SYRUP.
Q: Is OFLOTAS OZ SYRUP safe to use in children with heart problems?
A: OFLOTAS OZ SYRUP should be administered with caution in children with leaking heart valves (heart valve regurgitation), endocarditis (infection of the heart), irregular or slow heartbeat, family history of prolonged QT interval, weak heart (heart failure), family history of heart attack (myocardial infarction). Consult your child’s doctor for advice before administration of OFLOTAS OZ SYRUP.
Q: Can OFLOTAS OZ SYRUP be used in children with kidney problems?
A: OFLOTAS OZ SYRUP should be administered with caution in children with kidney disease or problems. Your child’s doctor may monitor the child’s kidney function test before and during management with OFLOTAS OZ SYRUP to manage any unusual effects or kidney damage. Consult your child’s doctor for advice before administration of OFLOTAS OZ SYRUP.
Q: How does OFLOTAS OZ SYRUP work?
A: OFLOTAS OZ SYRUP is a combination of Ornidazole and Ofloxacin where Ornidazole kills parasites and bacteria that live in the absence of oxygen by generating harmful molecule which damages the DNA of the parasites and bacteria and ofloxacin is a quinolone antibiotic that kills bacteria by inhibiting the synthesis of bacterial DNA, hence helps to manage various infections.
Q: What are the common side effects of OFLOTAS OZ SYRUP?
A: The common side effects of taking OFLOTAS OZ SYRUP are nausea, vomiting, diarrhea, headache, itching, sleep problems and changes in taste sensation. Consult your child’s doctor immediately if any of the side effects worsen during or after management with OFLOTAS OZ SYRUP.
References
1. KD. Tripathi. Antimicrobial drugs, antiamoebic and other antiprotozoal drugs. Essentials of medical pharmacology. 8th Edition. 2019. Page-763 & 897.
2. A. Soni, M. Chaudhary, A. Tamta, R. Sehgal, S.M. Shrivastava and V.K. Dwivedi. Science Alert. Therapeutic Efficacy of Ofloxacin and Ornidazole vs Mebatic: Toxicity Profile and Antioxidant Defense Study. [Revised in 2009] [Accessed on 3rd May 2022] https://scialert.net/fulltext/?doi=jp.2009.79.86
3. David G. Bailey, George Dresser and J. Malcolm O. Arnold, MB. National Library of Medicine (NIH). Grapefruit–medication interactions: Forbidden fruit or avoidable consequences. [Revised in 18th October 2018] [Accessed on 3rd May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589309/
4. Cologne, Germany: Institute for Quality and Efficiency in Health Care (IQWiG). National Library of Medicine (NIH). Using medication: Using antibiotics correctly and avoiding resistance. [Revised in 13th December 2013] [Accessed on 3rd May 2022] https://www.ncbi.nlm.nih.gov/books/NBK361005
5. Shalina Healthcare. Shalflod (Ofloxacin 50 mg and Ornidazole 125 mg) Suspension. [Accessed on 3rd May 2022] https://www.shalina.com/wp-content/uploads/2018/09/shalflodgroup.pdf
Useful Diagnostic Tests
- Complete blood count
- Liver function test
- Kidney function test
- Bacterial Culture sensitivity test
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