Nucarnit E Capsule 15'S
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Introduction About NUCARNIT E CAPSULE
NUCARNIT E CAPSULE contains Levocarnitine, which belongs to the group of medicines called Amino acid derivatives. It is used to manage levocarnitine deficiency. Levocarnitine deficiency can occur either due to a systemic deficiency at birth, various metabolic disorder or due to end-stage kidney disease and haemodialysis management.
The symptoms of levocarnitine deficiency may include muscle weakness (muscles of the hips, shoulders, neck, jaw and even heart muscles), fatigue, low blood sugar, stomach pain, growth retardation, brain function defects, etc.
Before taking NUCARNIT E CAPSULE, your doctor may want you to take blood tests to check for the existing amount of levocarnitine in circulation to determine the correct dosage for you. NUCARNIT E CAPSULE is not recommended for use in patients with a history of fits or severely compromised renal function. Before taking this medicine, inform your doctor if you have diabetes.
NUCARNIT E CAPSULE should be used with caution among pregnant or breastfeeding women; therefore, consult your doctor before taking it. The most common side effects of taking NUCARNIT E CAPSULE are vomiting, nausea, stomach pain, diarrhea, headache, an abnormal taste or body odour (a fishy smell). Contact your doctor if any of your symptoms get worse.
Uses Of NUCARNIT E CAPSULE
NUCARNIT E CAPSULE is used to manage:
- primary systemic carnitine deficiency by birth
- secondary carnitine deficiency due to certain metabolic disorders that result in the accumulation of abnormal and toxic metabolites (Ex. methyl malonic aciduria, propionic acidemia, glutaric aciduria and medium chain fatty acetyl dehydrogenase deficiency
- secondary carnitine deficiency due to hemodialysis
How NUCARNIT E CAPSULE Works
NUCARNIT E CAPSULE helps to manage levocarnitine deficiency which is a naturally occurring substance in the body. It is utilized in the process of energy production. This helps in sustaining the muscular activity of the heart and other muscles.
How to use NUCARNIT E CAPSULE
NUCARNIT E CAPSULE is to be taken as advised by the doctor. Take the medicine preferably after meals. Use water to swallow it. Do not crush or chew NUCARNIT E CAPSULE. Your doctor will decide the correct dose and duration for you, depending on your age, body weight and disease conditions.
Side Effects Of NUCARNIT E CAPSULE
Common
- vomiting
- nausea
- upset stomach
- diarrhea
- stomach pain
- abnormal taste
- body odour (fish-like smell)
- headache
Rare
Stop taking NUCARNIT E CAPSULE and consult your doctor immediately if you experience any of the following:
- signs of allergic reaction such as difficulty swallowing or breathing, hives, swelling of the face, lips, tongue or throat, rash
- unexplainable muscle pain, muscle tenderness or weakness, dark brown urine (Rhabdomyolysis)
- signs of increased levels of calcium such as increased thirst, frequent urination, nausea, vomiting, constipation, pain in bones, confusion and fatigue
- signs of high blood pressure such as headache, dizziness, vision problems, shortness of breath
- palpitations
- signs of decreased blood platelet count such as bleeding or bruising, fatigue and weakness
- signs of anemia such as fatigue, loss of energy, weakness, shortness of breath
- signs of bronchitis such as coughing and difficulty breathing
- low blood sugar
- fits (seizures)
- signs of dermatitis exfoliative such as rashes, redness, widespread blistering or peeling of the skin and mucosa (mouth)
How To Manage Side Effects
Nausea and Vomiting:
Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if it persists for a long or worsens with time.
Difficulty in breathing (Dyspnea):
Take slow deep breaths. Perform breathing exercises. Try to seek medical help immediately.
Headache:
Stay hydrated and take rest as much as possible. Stay away from harsh lights and loud sounds. Apply a pain-relieving balm on the forehead.
Tiredness:
Drink plenty of fluids and electrolytes and eat a balanced diet with an increased frequency of meals. Try to do regular minimal exercise and follow a proper sleep schedule. If the symptom does not improve consult your doctor for the same.
Warning & Precautions
Pregnancy
NUCARNIT E CAPSULE must be used with caution in pregnant women and those who are planning to get pregnant due to a lack of safety data. Consult your doctor before taking NUCARNIT E CAPSULE.
Breastfeeding
NUCARNIT E CAPSULE must be used with caution in nursing women due to a lack of safety data. Consult your doctor before taking NUCARNIT E CAPSULE.
Driving and Using Machines
NUCARNIT E CAPSULE is considered safe for driving or while using machinery. However, consult the doctor before you take it.
Kidney
NUCARNIT E CAPSULE is not recommended for use in patients having severely compromised renal function as it may lead to toxic metabolites being accumulated in the kidney. This medicine must be used cautiously in patients suffering from kidney disorders and undergoing hemodialysis. Consult your doctor before taking NUCARNIT E CAPSULE.
Allergy
Do not take NUCARNIT E CAPSULE if you are allergic to Levocarnitine.
Others
NUCARNIT E CAPSULE is not recommended for use if you:
- have a history of fits (seizure activity) as it may lead to a rise in the frequency, duration and severity of the seizures
Before taking NUCARNIT E CAPSULE, inform your doctor if you:
- have diabetes
- are on a reduced-calorie diet
- have a disorder of kidney
- are intolerant to some sugars
Use in Pediatrics:
NUCARNIT E CAPSULE must be used with caution in pediatric patients and should be taken based on their age, body weight and disease condition. Consult your doctor before taking it.
Interactions
A. Drug-Drug Interactions:
Before taking NUCARNIT E CAPSULE, inform your doctor if you are taking any of the following medicine:
- medicines used to manage blood clots (Ex. Warfarin, Heparin, Aspirin, Clopidogrel)
- medicines to manage elevated blood sugar levels Ex. Insulin, Metformin etc.)
Overdosage:
If you or anyone else accidentally take too much of NUCARNIT E CAPSULE, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are upset stomach and/or diarrhea.
Synopsis
| Drug | : | Levocarnitine |
| Pharmacological Category | : | Amino acid derivatives |
| Therapeutic Indication | : | Carnitine deficiency |
| Dosage Forms | : | Tablet, Capsule, Syrup, Injection |
More Information
- Keep NUCARNIT E CAPSULE out of reach from children
- Store at a controlled room temperature of 25°C
- Keep it away from moisture and sunlight
FAQs About NUCARNIT E CAPSULE
What is NUCARNIT E CAPSULE used for?
NUCARNIT E CAPSULE is used to manage carnitine deficiency, which can occur at birth, as a result of certain metabolic disorders or as a result of a medical procedure such as hemodialysis.This reduced level of levocarnitine results in decreased energy, leading to muscle weakness. NUCARNIT E CAPSULE helps manage these symptoms by managing the deficiency.
How should NUCARNIT E CAPSULE be stored?
NUCARNIT E CAPSULE should be stored at a controlled room temperature of 25°C. It is recommended not to store it in the refrigerator. Keep it away from humidity and sunlight. It is recommended to not store NUCARNIT E CAPSULE after removal from the foil package.
What medications should I not take before or after taking NUCARNIT E CAPSULE?
Anti-diabetic medications (Ex. Insulin, Metformin), blood-thinning medications (Ex. Aspirin) and medications to manage blood clots (Ex. Heparin, Warfarin) are not recommended to be taken along with NUCARNIT E CAPSULE as they may lead to unwanted side-effects. Inform your doctor about all the medicinal and/or surgical managements that you were, are or will be undergoing before taking NUCARNIT E CAPSULE.
Can I drive my way back home after taking NUCARNIT E CAPSULE?
Yes, you can drive after taking NUCARNIT E CAPSULE since NUCARNIT E CAPSULE has not been reported to cause disturbance while driving or using machinery. However, consult your doctor before taking NUCARNIT E CAPSULE.
Is it normal to experience body odour after taking NUCARNIT E CAPSULE?
Yes, body odour is a common side effect usually seen after taking NUCARNIT E CAPSULE. Apply a mild deodorant or perfume to the skin to manage it. However, it should be brought to the attention of your doctor if it worsens with time.
Can I take NUCARNIT E CAPSULE if I am pregnant?
Before taking NUCARNIT E CAPSULE, it is recommended that you consult your doctor and inform him if you are pregnant or planning to become pregnant, as its effects have not been studied in pregnant women.
References
1. KD. Tripathi. Miscellaneous drugs. Vitamins. Essentials of Medical Pharmacology. Seventh edition. 2013. Page 912.
2. Sakurauchi, Y., Matsumoto, Y., Shinzato, T., Takai, I., Nakamura, Y., Sato, M., Nakai, S., Miwa, M., Morita, H., Miwa, T. and Amano, I., 1998. Effects of L-carnitine supplementation on muscular symptoms in hemodialyzed patients. American journal of kidney diseases [Available on 1st August 1998] [Accessed on 19th July 2022] https://www.ajkd.org/article/S0272-6386(98)00208-X/fulltext#relatedArticles
3. Matsumoto, Y., Sato, M., Ohashi, H., Araki, H., Tadokoro, M., Osumi, Y., Ito, H., Morita, H. and Amano, I., 2000. Effects of L-carnitine supplementation on cardiac morbidity in hemodialyzed patients. American journal of nephrology [Published on 30th June 2000] [Accessed on 19th July 2022] https://www.karger.com/Article/Abstract/13584
4. sigma-tau Pharmaceuticals, Inc. U.S Food and Drug Administration. [Available on 15th April 2002] [Accessed on 19th July 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2002/18948S22lbl.pdf
5. Sigma-Tau Pharmaceuticals, Inc. U.S Food and Drug Administration. [Available in June 2006] [Accessed on 19th July 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/018948s024,019257s011lbl.pdf
6. Leadiant Biosciences, Inc. Levocarnitine. [Revised in November 2017] [Accessed on 19th July 2022] https://pdf.hres.ca/dpd_pm/00041980.PDF .
Useful Diagnostic Tests
- Carnitine test – Blood test
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